What wine goes with spaghetti & meatballs? The best wines to pair with Spaghetti & Meatballs are medium-bodied Italian red wines such as Chianti Classico, Barbera, Primitivo, Valpolicella and Montepulciano. Italian red wines have ample acidity to deal with the tomato sauce and plenty of tannin to bite into the meatballs, all along…